Lakeside charm just off the beaten path. Between Columbia and Charleston, on the banks of a quaint branch of South Carolina's largest lake, lies a charming & comfortable home-base for your forays into the heart of the state. Wyndham Vacation Resorts Santee sits right on the shore of Lake Marion's Chapel Branch, a calm, tree- lined waterway that creates the perfect escape for you and your family. With outdoor activities in every direction and a location that's convenient to drive to more heavily populated pursuits, you won't need to go far to find your own brand of fun.